Recently, Quyn et al. demonstrated that cells within the stem cell zone of human and mouse intestinal crypts tend to align their mitotic spindles perpendicular to the basal membrane of the crypt. This is associated with asymmetric division, whereby particular proteins and individual chromatids are preferentially segregated to one daughter cell. In colonic mucosa containing a heterozygous adenomatous polyposis coli gene (APC) mutation the asymmetry is lost. Here, we discuss asymmetric stem cell division as an anti‐tumourigenic mechanism. We describe how (...) hierarchical tissue structures suppress somatic evolution, and discuss the relative merits of template strand retention to limit the accumulation of DNA replication errors. We suggest experiments to determine whether somatic mutations resulting in loss of spindle alignment confer an advantage within the stem cell niche. Finally, we discuss whether lack of spindle alignment constitutes an oncogenic event per se, with particular reference to studies in model organisms, and the timing of chromosomal instability in human cancers. (shrink)

The Canadian province of Ontario introduced philosophy as a secondary school subject in 1995 (Pinto, McDonough, & Boyd, 2009). Since publicly-funded Catholic schools teach approximately 32% of all students in Ontario (Ontario Ministry of Education, 2022), the question arises regarding how teachers in those schools coordinate philosophy and Catholic teachings. This study employs a secondary analysis of interviews with six teachers from Ontario’s Catholic schools, and employs two of Avery Dulles’ (2002) conceptions of church (institution and mystical communion) to determine (...) how they consider the choices available within their own tradition that could answer this question. Rather than looking only at the shortcomings of treating magisterial teaching as philosophy, this paper argues that there are also conceptual problems that these courses must address in order to improve their ecclesiological adequacy, and illustrates how an apparent null curriculum privileges the institutional ecclesiology. (shrink)

"This innovative volume argues that any particular kind of music can only be understood in terms of the criteria of the group which makes and appreciates that music. This theme is in sharp contrast to established attitudes to music which utilize 'objectively' conceived aesthetic. These attitudes are revealed in the assumptions underlying most musicology and musical aesthetics including, perhaps paradoxically, the work of a number of cultural radicals such as Lukacs and Adorno. On a more practical level, they manifest themselves (...) both in music education policies and in the policies of arts and broadcasting administrators, who have the power to promote some kinds of music above others. (shrink)

Constraints on the types of speech errors observed can be accounted for by a frame/content distinction, but connectionist modeling shows that they do not require this distinction. The constraints may arise instead from the statistical properties of our language, in particular, the sequential biases observed in the vocabulary. Nevertheless, there might still be a role for the frame/content distinction in syntactic planning.

I examine four core aspects of WEAVER ++. The necessity for lemmas is often overstated. A model can incorporate interaction between levels without feedback connections between them. There is some evidence supporting the absence of inhibition in the model. Connectionist modelling avoids the necessity of a nondecompositional semantics apparently required by the hypernym problem.

The Problem of Consciousness This chapter will introduce you to consciousness and its most important characteristics. We will look at definitions of consciousness, and examine what it means to say that consciousness is a private experience. We will look at the idea that it is like something to be you or me. The chapter mentions ideas and themes that will be covered in more detail in the rest of the book, and explains why the topic is an important one. Research (...) on consciousness is big on questions but shorter on answers. Nevertheless these questions are central to what it means to be human, or indeed at the heart of what it's like to be anything - what it's like to be conscious. Think of yourself just now. What does it feel like you to be you right at this moment? Think of a loved one. What do you think it is like to be them? Do they know exactly what they're feeling, and do you know just what they're feeling? We might have some idea, but the answer in both cases is no, and not only "no", we can't see how we ever could know for sure. It's my consciousness and your consciousness. (shrink)

This paper considers the claim that imagination is implicated in our most apparently straightforward human transactions with the world, that our 'knowing' of the world (both in experience and our subsequent symbolic ordering of it) is in some sense imaginatively constructed from the outset. Second, drawing in particular on the work of Mark Johnson, it explores the senses in which such imaginative transactions are both experience constituted and experience constitutive (that, in Ricoeur's words, imagination 'invents in both senses of the (...) word'). Third, it attends to one apparent theological cost of ascribing to human imagination a 'creative' role in relation to the human world. Fourth, it focuses in particular on Charles Taylor's account of the imaginative construction of the self as a moral entity. And finally, it considers just one example of how the arts may be active in shaping moral identity, and thereby the human world in which we live and move and have our being. (shrink)

2000 Years and Beyond brings together some of the most eminent thinkers of our time - specialists in philosophy, theology, anthropology and cultural theory. In a horizon-scanning work, they look backwards and forwards to explore what links us to the matrix of the Judaeo-Christian tradition from which Western cultural identity has evolved. Their plural reflections raise searching questions about how we move from past to future - and about who 'we' are. What do the catastrophes of the twentieth century signify (...) for hopes of progress? Can post - Enlightment humanism and its notion of human nature survive without faith? If the 'numinous magic global capitalism' is our own giant shadow cast abroad, does that shadow offer hope enough of a communal future? Has the modern, secularized West now outgrown its originating faith matrix? Often controversial and sometimes visionary, these seven new essays ask: how do we tell - and rewrite - the story of the Common Era? Introduced by Paul Gifford, and discussed in a lively dialogic conclusion, they add their distinctive voices to a debate of profound and urgent topicality. (shrink)

The history of the Euclidean Steiner tree problem, which is the problem of constructing a shortest possible network interconnecting a set of given points in the Euclidean plane, goes back to Gergonne in the early nineteenth century. We present a detailed account of the mathematical contributions of some of the earliest papers on the Euclidean Steiner tree problem. Furthermore, we link these initial contributions with results from the recent literature on the problem.

We present one of the first quantitative studies on auditory verbal experiences and auditory verbal agency voices or characters”) in healthy participants across states of consciousness. Tools of quantitative linguistic analysis were used to measure participants’ implicit knowledge of auditory verbal experiences and auditory verbal agencies, displayed in mentation reports from four different states. Analysis was conducted on a total of 569 mentation reports from rapid eye movement sleep, non-REM sleep, sleep onset, and waking. Physiology was controlled with the nightcap (...) sleep–wake mentation monitoring system. Sleep-onset hallucinations, traditionally at the focus of scientific attention on auditory verbal hallucinations, showed the lowest degree of VE and VA, whereas REM sleep showed the highest degrees. Degrees of different linguistic-pragmatic aspects of VE and VA likewise depend on the physiological states. The quantity and pragmatics of VE and VA are a function of the physiologically distinct state of consciousness in which they are conceived. (shrink)

The _Physics_ is a foundational work of western philosophy, and the crucial one for understanding Aristotle's views on matter, form, essence, causation, movement, space, and time. This richly annotated, scrupulously accurate, and consistent translation makes it available to a contemporary English reader as no other does—in part because it fits together seamlessly with other closely associated works in the New Hackett Aristotle series, such as the _Metaphysics_, _De Anima_, and forthcoming _De Caelo_ and _On Coming to Be and Passing Away_. (...) Eventually the series will include all of Aristotle's works. Sequentially numbered endnotes provide the information most needed at each juncture, while a detailed Index of Terms indicates places where focused discussion of key notions occurs. An illuminating general Introduction describes the book that lies ahead, explaining what sort of work it is and what sorts of evidence it relies on. (shrink)

We present one of the first quantitative studies on auditory verbal experiences (“hearing voices”) and auditory verbal agency (inner speech, and specifically “talking to (imaginary) voices or characters”) in healthy participants across states of consciousness. Tools of quantitative linguistic analysis were used to measure participants’ implicit knowledge of auditory verbal experiences (VE) and auditory verbal agencies (VA), displayed in mentation reports from four different states. Analysis was conducted on a total of 569 mentation reports from rapid eye movement (REM) sleep, (...) non‐REM sleep, sleep onset, and waking. Physiology was controlled with the nightcap sleep–wake mentation monitoring system. Sleep‐onset hallucinations, traditionally at the focus of scientific attention on auditory verbal hallucinations, showed the lowest degree of VE and VA, whereas REM sleep showed the highest degrees. Degrees of different linguistic‐pragmatic aspects of VE and VA likewise depend on the physiological states. The quantity and pragmatics of VE and VA are a function of the physiologically distinct state of consciousness in which they are conceived. (shrink)

A principle that many have found attractive is one that goes by the name “'Ought' Implies 'Can'.” According to this principle, one morally ought to do something only if one can do it. This essay has two goals: to show that the principle is false and to undermine the motivations that have been offered for it. Toward the end, a proposal about moral obligation according to which something like a restricted version of 'Ought' Implies 'Can' is true is floated. Though (...) no full-fledged argument for this proposal is offered, that it fits with a rather natural and intuitive picture of the structure of morality and seems to explain certain salient features of the debate over whether the principle is true, goes some way toward recommending it. (shrink)

This is a philosophical investigation of the nature of the limits of thought. Drawing on recent developments in the field of logic, Graham Priest shows that the description of such limits leads to contradiction, and argues that these contradictions are in fact veridical. Beginning with an analysis of the way in which these limits arise in pre-Kantian philosophy, Priest goes on to illustrate how the nature of these limits was theorised by Kant and Hegel. He offers new interpretations of (...) Berkeley's master argument for idealism and Kant on the antimonies. He explores the paradoxes of self reference, and provides a unified account of the structure of such paradoxes. The book concludes by tracing the theme of the limits of thought in modern philosophy of language, including discussions of the ideas of Wittgenstein and Derrida. (shrink)

In this book, Graham Oppy examines arguments for and against the existence of God. He shows that none of these arguments is powerful enough to change the minds of reasonable participants in debates on the question of the existence of God. His conclusion is supported by detailed analyses of the arguments as well as by the development of a theory about the purpose of arguments and the criteria that should be used in judging whether or not arguments are successful. (...) Oppy discusses the work of a wide array of philosophers, including Anselm, Aquinas, Descartes, Locke, Leibniz, Kant, Hume and, more recently, Plantinga, Dembski, White, Dawkins, Bergman, Gale and Pruss. (shrink)

This is a revised and updated edition of Graham Nerlich's classic book The Shape of Space. It develops a metaphysical account of space which treats it as a real and concrete entity. In particular, it shows that the shape of space plays a key explanatory role in space and spacetime theories. Arguing that geometrical explanation is very like causal explanation, Professor Nerlich prepares the ground for philosophical argument, and, using a number of novel examples, investigates how different spaces would (...) affect perception differently. This leads naturally to conventionalism as a non-realist metaphysics of space, an account which Professor Nerlich criticises, rejecting its Kantian and positivistic roots along with Reichenbach's famous claim that even the topology of space is conventional. He concludes that there is, in fact, no problem of underdetermination for this aspect of spacetime theories, and offers an extensive discussion of the relativity of motion. (shrink)

Teleosemantics seeks to explain meaning and other intentional phenomena in terms of their function in the life of the species. This volume of new essays from an impressive line-up of well-known contributors offers a valuable summary of the current state of the teleosemantics debate.

Graham Nerlich is one of the most distinguished of contemporary philosophers of space and time. Eleven of his essays are here brought together in a carefully structured volume, which deal with ontology and methodology in relativity, variable curvature and general relativity, and time and causation. The author has provided a new general introduction and also introductions to each part to bring the discussion more up to date and draw out the general themes. The book will be welcomed by all (...) philosophers of physics, and of science in general. (shrink)

In Chapters 6 and 7 of Language, Truth and Poetry I attempted to solve the ancient problem of fictional reference by claiming that a fictional construct ‘points’ or refers to certain features of reality in rather the same way as an abstraction like ‘gravitation’ or ‘cruelty’ does. I now believe that this theory of mine is unsatisfactory; and I should like to propose a new solution to the problem.

It is shown that the Kapitza-Dirac effect with atoms, which has been considered to be evidence for their wavelike character, can be interpreted as a scattering of pointlike objects by the periodic laser field.

Originally published in 1980, this book examines the major issues in the philosophy of social science, paying specific attention to cross-cultural understanding, humanism versus scientism, individualism versus collectivism, and the shaping of theory by evaluative commitment. Arguing for a cross-cultural conception of human beings, the authors defend humanism and individualism, and reject the notion that social inquiry is necessarily vitiated by an adherence to values.

In this book Keith Graham examines the philosophical assumptions behind the ideas of group membership and loyalty. Drawing out the significance of social context, he challenges individualist views by placing collectivities such as committees, classes or nations within the moral realm. He offers an understanding of the multiplicity of sources which vie for the attention of human beings as they decide how to act, and challenges the conventional division between self-interest and altruism. He also offers a systematic account of (...) the different ways in which individuals can identify with or distance themselves from the groups to which they belong. His study will be of interest to readers in a range of disciplines including philosophy, politics, sociology, law and economics. (shrink)

As inter‐organisational relations represent an increasingly important element in business the ability to build sustainable relationships becomes a key skill. To achieve sustainable relationships parties need to move from a low trust/low ethics base to a high trust/high ethics base in their relating. This paper uses data from a study into trust‐based partnering in the construction industry to demonstrate that ethics is integral to trust building. The data supports the proposition that ethical partnering, which is characterised by reliability, delivery of (...) promises, open and honest communications, respect and reciprocity, and a willingness to act reasonably towards each other, is the most effective model for parties seeking to build sustainable relationships. (shrink)

The cognitive science of religion draws on insights from evolutionary psychology, and offers explanations of religious belief based on natural cognitive processes. This article examines a number of competing explanations of religious belief by considering it as a solution to the challenge of cooperation. The challenge of stopping individuals cheating within a cooperative group has been a problem throughout humanity’s evolutionary history. Empirical evidence drawn from fields such as anthropology and psychology suggests that religious beliefs are part of an evolved (...) cognitive system that motivates individuals to cooperate with other members of their group. Three possible evolutionary accounts, the memetic, by‐product, and adaptation accounts, are considered as evolved solutions to the challenge of cooperation. (shrink)

Causality plays an important role in medieval philosophical writing: even before the rediscovery of Aristotle's major works, the created universe was seen as a rational manifestation of God's action. In the later Middle Ages, the dominant genre of medieval academic writing was the commentary on an authoritative work: Aristotle's Physics and Metaphysics were frequently commented on, and both contain a great deal of material on causation. So the nature of the philosophical and theological themes which were popular in the Middle (...) Ages led to an emphasis on causality. Writers studied the interrelationship of divine grace and natural processes, the role of the will in ethics, free will and determinism: all of these problems have an important causal component. (shrink)

Atheism: The Basics is a concise and engaging introduction to belief in the non-existence of deities. Atheism has long fascinated people but debate around this controversial position may seem daunting. In this lively and lucid book, Graham Oppy addresses the following important questions: -/- • What does it mean to be an atheist? -/- • What is the difference between atheism, agnosticism, theism and innocence? -/- • How has atheism been distributed over time and place? -/- • What does (...) science tell us about atheism? -/- • Are there good reasons to be an atheist? -/- • Are there good reasons not to be an atheist? -/- • What do we mean by ‘new atheism'? -/- With a glossary of key terms and suggestions for further reading throughout, the book considers key philosophical arguments around atheism, making this an ideal starting point for anyone seeking a full introduction to the arguments between those who hold atheistic beliefs and those who do not. (shrink)

_The Internet: A Philosophical Inquiry_ develops many of the themes Gordon Graham presented in his highly successful radio series, _The Silicon Society_. Exploring the tensions between the warnings of the Neo-Luddites and the bright optimism of the Technophiles, Graham offers the first concise and accessible exploration of the issues which arise as we enter further into the world of Cyberspace. This original and fascinating study takes us to the heart of questions that none of us can afford to (...) ignore: how does the Internet affect our concepts of identity, moral anarchy, censorship, community, democracy, virtual reality and imagination? Free of jargon and full of stimulating ideas, this is essential reading for anyone wishing to think clearly and informatively about the complexities of our technological future. (shrink)

This chapter contains sections titled: Central Issues in the Historical Dispute Resolving Issues over Kant's Position Kant's Arguments for his Claims.

Beginning from an earlier claim of mine that there was really no such area of study as the philosophy of sport, Part One of the paper reconsiders the place previously given to David Best’s distinction between purposive sports and aesthetic sports. In light of a famous cricketing event in the 1977 contest between England and Australia (‘The Ashes’), in which Derek Randall turned a cartwheel after taking the winning catch, the paper clarifies that not all aesthetically-pleasing events taking place in (...) sporting competitions can be understood as the aesthetic in sport. Then, in Part Two, the force of the claim that philosophy is one subject is explored. The conclusion is that a focus just on the philosophy of sport is necessarily inappropriate, since it will present the student with only cases from sport to then apply to sport. Rather, one’s understanding must be informed by (much of) the breadth of philosophy. Charles Travis’s view of occasion-sensitivity provides a clear example of appropriately contextual appeal. Part Three of the paper returns to the need for an institutional account of sport, one recognizing that there is no one occasion on which a particular sport is played; and hence no single set of conditions which can uniquely identify that sport. Thus, soccer played with one’s children typically differs from elite soccer: but both are (genuinely) soccer. When one turns to the appreciation of sport (in the light of Stephen Mumford’s excellent Watching Sport: Aesthetics, Ethics and Emotion [2012a]), one recognizes that, in order to genuinely appreciate sport, one cannot detach oneself from the outcome as completely as Mumford’s extreme purist seems to. But reflection on that case may also return us to contextualism by moving us away from attachments to the complete or the exceptionless in our accounts of spectating as of sport: maybe there is no one thing that occurs in all the relevant cases. (shrink)

Most academic efforts to understand morality and ideology come from theorists who limit the domain of morality to issues related to harm and fairness. For such theorists, conservative beliefs are puzzles requiring non-moral explanations. In contrast, we present moral foundations theory, which broadens the moral domain to match the anthropological literature on morality. We extend the theory by integrating it with a review of the sociological constructs of community, authority, and sacredness, as formulated by Emile Durkheim and others. We present (...) data supporting the theory, which also shows that liberals misunderstand the explicit moral concerns of conservatives more than conservatives misunderstand liberals. We suggest that what liberals see as a non-moral motivation for system justification may be better described as a moral motivation to protect society, groups, and the structures and constraints that are often (though not always) beneficial for individuals. Finally, we outline the possible benefits of a moral foundations perspective for System Justification Theory, including better understandings of 1) why the system-justifying motive is palliative despite some harmful effects, 2) possible evolutionary origins of the motive, and 3) the values and worldviews of conservatives in general. (shrink)